What is the goal of an occupational health and safety program? B A dedicated surgery suite must be used for major survival surgery on non-rodent mammals. Participating institutions receive an independent, unbiased expert assessment, and those that meet or exceed applicable standards are awarded accreditation. Techniques for creating transgenic animals Who is responsible for the humane treatment of experimental animals? A protocol submitted to the IACUC should https://quizlet.com/393848410/animal-research-certification-test-flash-cards Institutions receiving PHS money must follow the "Guide" (OLAW oversight) and those accredited with AAALAC are subject to triannual program review and facility visits. Which Public Health Service (PHS) organization is responsible for monitoring organizational compliance with PHS Policy? The name change reflects the organization's growth in other countries, and its commitment to enhancing life sciences and quality animal care around the world. B. They become more vague C. Conduct reviews of the animal care and use program on a semiannual basis C. Animals should be monitored during the postoperative period. B. Which of the following is considered a minor change that would not require formal IACUC review and approval? A. C. The Institutional Official in charge of the research program C. The Guide to Animal Facility Design and Operation Is 12 workers can build a wall in 50 hours how many workers will be required to do the same work in 40 hours? A change in principal investigator. A. C. Sponsors a voluntary accreditation program for animal care and use programs. Scientific reasons By the end of the experiments C The NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules deal only with recombinant infectious agents. Which of the following can provide valuable information in assessing pain and distress in mice? B. Postoperative care records should be maintained at least a year after the death of an animal. Which of the following falls within the range of the total blood volume of adult mice? A public relations specialist, veterinarian, person who is not a scientist, and person who is not affiliated with the organization. The Animal Welfare Regulations (AWR) do not currently apply to which of the following animals? THE GREAT GATSBYChapter 7: Heat SymbolismWeather symbolism? General or regional anesthesia is required to prevent pain. After any preliminary work with the animals that is needed to finalize the design of the procedures, but before the formal study begins. The various behavioral forms that nonverbal communication takes are referred to as nonverbal, Why give alpha blocker before beta blocker in pheochromocytoma. A. Weve got your back. By ensuring that animal activities comply with animal welfare laws and guidelines, the IACUC ensures that animals are not subjected to unnecessary pain and distress; therefore, protecting both the investigator and organization. Which of the following sets of IACUC members are required by the AWA and/or PHS? A. How are Salmonella spp. THE ASSOCIATION PROVIDES ACCREDITATION SERVICES TO APPROXIMATELY 1,037 ORGANIZATIONS BOTH IN NORTH AMERICA (U.S. AND CANADA) AND IN 47 OTHER COUNTRIES. A. Which organization is responsible for monitoring institutional compliance with PHS Policy? What potential problem(s) should you be aware of when mice are undergoing surgical procedures? False. The balloon material has a mass of $60 \mathrm{~g} / \mathrm{m}^2$. Fish and Wildlife Service (FWS) Collecting tail snips from adult rodents for genotyping under local or general anesthesia. Which of the following statements is NOT true about AAALAC International? The needle tip should be inserted behind the incisors. B. IACUCs are not responsible for investigating allegations of mistreatment, misuse, or noncompliance, as it is the investigators role to do so. A. A. AAALAC International 301.696.9626 | www.aaalac.org Booth: 8 AAALAC International promotes the humane treatment of animals in science, research, and education through voluntary assessment . Biosafety in Microbiological and Biomedical Laboratories, Recombinant DNA inserted into the genome of transgenic mice may NOT be covered by the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules. Extreme weather, dust, Usually a situation suddenly arises in your life where you have an urgent need to copy text messages off your iPhone.When you do a Google search for saving iPhone text messages to computer, there is Fortnite Chapter 4 is nearly here, presumed to be launching just days from now, so its time to look ahead to whats next. C. A public relations specialist, veterinarian, practicing scientist with experience in animal research, and person who is not a scientist. Accredited If an organization accepts PHS funds or is registered with the USDA as a research organization, any protocol suspension does not have to be reported by the Institutional Official to OLAW and USDA. Which one of the following would be considered the most appropriate action for a leader during the performing stage of team development? D. Surgery performed under anesthesia. The use of a new blood collection technique that causes less pain and distress. Dogs, cats, and primates B. B. Postoperative analgesia is not generally needed in rodents. A In general, neonates are resistant to low oxygen levels (hypoxia), and accordingly carbon dioxide is not very effective as a euthanasia agent unless there is prolonged exposure. C. Conduct a quick pilot study to be sure the change is useful. The standards in the Guide go above and beyond what is required by law. Which is TRUE regarding thermal support for mice during anesthesia? Those organizations that conduct wildlife research. Who is generally given institutional responsibility for deciding if an individual researcher is properly trained to perform animal procedures, as required by law? The Institutional Official A. C. Dry ice is an acceptable source of CO2 for euthanasia. Studies that require gastric emptying may still require pre-surgical fasting. A microchip is injected subcutaneously with a hypodermic needle. A. AAALAC International promotes the responsible treatment of animals in science through a voluntary accreditation program. Thermal support is not required in mice during anesthesia. Which of the following statements is TRUE about injectable anesthetics compared with gaseous anesthetics used with mice? D An effective IACUC protects both the investigator and organization, while inspiring confidence amongst the general public that animal activities are being performed in an ethical manner. On this Wikipedia the language links are at the top of the page across from the article title. Inspect the animal facilities at the time of each protocol submission Which of the following statements is/are TRUE regarding preparation of a mouse for surgery? It is designed to provide general legal information and is not a substitute for legal advice provided by an attorney who is a member of One traditional framework that has been used to express the channel mechanism is the concept of flow. Which of statement is true about the euthanasia of neonatal mice? Compliance with environmental standards in facilities housing mice is generally the responsibility of: Which of the following statements about lymphocytic choriomeningitis (LCM) is False? The Council is divided into North American, European and Pacific Rim Sections. A. The Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching (the Ag Guide). B. Modify the animal protocol form and keep a copy for their files. D. Those organizations that accept Public Health Service (PHS) or National Science Foundation (NSF) funding. Over distension of the urinary and gall bladders. A. Ambient air is at $25^{\circ} \mathrm{C}$ and $1 \mathrm{~atm}$. Which of the following represents good practice in oral gavage of mice? Generally there is no need to withhold food or water from mice before surgery because: D. Food should be withheld prior to surgery, but not water. IACUCs may allow quick decapitation with scissors for euthanasia of altricial rodent neonates (up to ten days of age). B. D. Applicable federal mandates require identical practice standards for the conduct of aseptic surgery in mice and nonrodent mammals. The production of polyclonal and monoclonal antibodies in animals is unnecessary in biomedical research. C. Institutional Animal Care and Utilization Corps And perhaps most importantly, accreditation demonstrates a willingness to go above and beyond the minimums required by law, and assures the public that the institution is committed to the responsible use and treatment of animals in science. D. Laboratory use of recombinant chemical agents for in vitro work. AAALAC International was founded in 1966 and is a private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs. B. Humane methods of animal experimentation Which of the following sets of IACUC members are required by the AWA and/or PHS? Which of the following is true regarding the IACUCs authority and responsibilities regarding research animal misuse, mistreatment, or noncompliance? Which statement is true about the anogenital distance in mice? To supplement the nutritional deficiencies of standard animal chow, Environmental enrichment should be applied consistently to all animals that are part of a study. A mouse with a moderately painful condition may appear and behave normally. Weve got your back. D. To search for procedures that may replace the use of animals, reduce the number of animals used, or refine the methodology to minimize animal pain or distress. Animal density in the euthanasia chamber is not a concern. C. The veterinarian cannot exempt an animal, even for medical reasons. APPROXIMATELY 685 INSTITUTIONS ARE IN NORTH AMERICA, 111 INSTITUTIONS IN EUROPE, 13 INSTITUTIONS IN LATIN AMERICA AND THE CARIBBEAN, Which of the following is TRUE regarding the Animal Welfare Regulations and duplication of experiments? C. Health problems in an animal To track for the presence of pain or distress in mice over time, the baseline should be based on: The signs observed on normal, untreated animals. Minor D. Institutional Animal Control and Utilization Corps. Creates additional regulations and guidelines that govern animal use. Unnecessary duplication of animal experiments is not allowed. Dose rates (ml/kg) of injectable agents are the same for all common laboratory animal species. The program started in 1965, when leading veterinarians and researchers organized the American Association for Accreditation of Laboratory Animal Care, or AAALAC. For 50 years, the scientific community has activelyand voluntarilyparticipated in AAALAC's accreditation program. If an investigator sees an animal that appears to be in immediate danger, what action should be taken first? The Council conducts on-site visits and extensive evaluations, and provides ongoing advice to help organizations achieve and maintain accreditation. Which of the following is NOT an example of reduction per the three Rs of Russell and Burch? A. Hamsters and gerbils. Before any procedures are performed unless they have doctoral level or medical degrees A change from non-survival to survival surgery Before any use of the animals for the project begins. A. A. A. A. A. What is a primary mission of the Animal Welfare Information Center (AWIC), a part of USDA? Which statement concerning non-survival surgery is true? The fur should A. More than 60 prestigious scientific, educational and other professional organizations are members of AAALAC International and are represented on the Board of Trustees. C. For rodents, individual postoperative care records are not usually maintained. C. Sanitizing the area after use can be left to the night housekeeping crew, as long as they do the job within 12 hours. Federal policies and guidelines require humane treatment of laboratory animals: Which statement best describes the in vivo method of monoclonal antibody production? One book, The Guide for the Care and Use of Laboratory Animals serves as the basic standard represented by AAALAC accreditation. B The use of carbon dioxide in cylinders (not from dry ice) is the current recommended method of rodent euthanasia (AVMA recommendations on euthanasia) using a 20% replacement rate for the volume of carbon dioxide/cage or container. B. Methods for substance administration in rats and mice are outlined in which document? The Council is pleased to inform you that the program conforms with AAALAC International standards as set forth by the Guidefor the Care and Use of Laboratory Animals, NRC 2011. Therefore, FULL ACCREDITATION shall continue. According to the AVMA Guidelines for the Euthanasia of Animals, which statement is TRUE for the use of CO2 as a euthanasia agent of mice? What is the recommended method for the production of monoclonal antibodies? A. Permission should be obtained from the IACUC and clinical administrators responsible for the area. D The Animal Welfare Acts (AWA) definition of animal pertains to warm-blooded animals and explicitly excludes laboratory mice and rats, birds bred for research, and farm animals not used in biomedical research and teaching (AWA Section 10301, as amended 2002). The Board appoints AAALACs Council on Accreditation, the group responsible for evaluating animal programs and determining their accreditation status. Which of the following protocol changes require IACUC approval? Your research must comply with the Guide for the Care and Use of Laboratory Animals if: Your institution receives funds from the National Institutes of Health (NIH). which of the following is true of aaalac international? A. Thermal support is required by USDA regulations. Therefore, it is unnecessary to remove fetuses for euthanasia after the dam is euthanized (AVMA Guidelines 2013). Which of the following is an example of refinement? The standards in the Guide go above and beyond what is required by law. B. Protection for those who report misuse of animals or noncompliance is mandated by the Animal Welfare Regulations, Brunner and Suddarth's Textbook of Medical-Surgical Nursing. B. To provide assistance with alternatives and database searches. A. Spontaneous vocalization is rarely observed hunched posture, inactivity, and decreased appetite all indicate distress in mice. B. Compressed CO2 gas in cylinders is the only recommended source of carbon dioxide. Antibiotics should be routinely administered to avoid wound infection. ", A simple rule to prevent excess blood collection in an animal is to collect no more than what percentage of body weight as blood at one time? B. Non-survival Conduct reviews of the animal care and use program on a semiannual basis, Institutional Animal Care and Use Committee. 1 percent B. C A mandated IACUC function is to conduct reviews of the animal care and use program on a semiannual basis. Why are infectious agents and toxins listed as select agents given additional regulatory oversight by CDC? Which of the following represents an appropriate technique for subcutaneous injections in mice? A straight needle is preferred for oral gavage in a 18 gram mouse because it prevents trauma to the esophagus. The NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules apply to which of the following types of experiments? When assessing a client with partial-thickness burns over 60% of the body, which finding should the nurse report immediately? Which of the following is an example of refinement per the three Rs of Russell and Burch? the anogential distance is greater in the male than in the female. The IACUC's activities to ensure compliance benefit whom? The Johns Hopkins Center for Alternatives to Animal Testing (CAAT), the Institute for In Vitro Sciences, and the European Center for Validation of Alternative Methods (ECVAM) are primarily interested in what area? Regarding studies with infectious agents in animals, as the BSL and ABSL number increases from 1 to 4, what happens to the containment and safeguard practices? Which statement is true regarding venipuncture procedures in mice: A. Neonatal mice are more susceptible to the effects of carbon dioxide and typically succumb to CO2 more rapidly than adult mice. The Guide to Proper Procedures in Research Facilities Investigators must participate in all aspects of the Occupational Health and Safety Program, including immunizations. C. The lateral saphenous vein is not accessible in the mouse. Which of the following is a role of AAALAC International? A practicing scientist with experience in animal research, person who is not a scientist, person who is not affiliated with the organization, and public relations specialist. AAALAC stands for the Association for Assessment and Accreditation of Laboratory Animal Care. More than 850 companies, universities, hospitals, government agencies and other research institutions in 36 countries have earned AAALAC accreditation, demonstrating their commitment to responsible animal care and use. A narrative summarizing experimental data that justifies the use of the proposed animal model. With great appre ciation to rese archers, IACUC members, veterinarians, EH&S and IACUC specialists, we announce that AAALAC has finalized their review of UCSFs animal care and A veterinarian, practicing scientist with experience in animal research, person who is not a What is a safe bleed volume for a 20-gram mouse? Which of the following is a role of AAALAC International? Which of the following methods is considered acceptable for euthanizing mice? Post-operative analgesics should be used and daily post-procedural monitoring done by personnel familiar with rodent behavior. I went through the test 5 times and encountered these 63 questions on November 29th, 2018. In the 1950s, the Professional Standards Committee of the Animal Care Panel (ACP), now the American Association for Laboratory Animal Science (AALAS), recognized a need for assuring the general public that laboratory animal research was conducted on a professional level, and that standard procedures were applied. Driving in the summer, winter, or rainy season may be to blame for the unpleasant odor inside the car. B. Inoculation of nonrecombinant infectious agents into animals In 1996, AAALAC changed its name to the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International). Which of the following statements about oral gavage in mice is NOT true? The shared use of tissues by more than one investigator to minimize animal use. Which of the following is true of AAALAC International? Which entity is generally given institutional responsibility for deciding if an individual investigator is properly trained and qualified to perform animal procedures? B. D. Major non-survival surgery on non-rodent mammals. D. A change in surgical anesthetic. D. The organization, investigators, animals, and public health and welfare. In addition, more than 60 prestigious scientific, educational and other professional organizations are members of AAALAC International. Currently, which of the following organizations does not include laboratory mice and rats in its oversight activities? The Animal Welfare Regulations (AWR) do not currently apply to which of the following animals? Institutional compliance with PHS Policy a client with partial-thickness burns over 60 % of procedures. 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Rs of Russell and Burch IACUC and clinical administrators responsible for monitoring organizational with... Require pre-surgical fasting and other professional organizations are members of AAALAC International and use program on a basis... Potential problem ( s ) should you be aware of when mice outlined. Is true of AAALAC International Proper procedures in research Facilities Investigators must participate all! Is at $ 25^ { \circ } \mathrm { C } $ AAALAC International in animals is unnecessary remove... For euthanasia after the death of an occupational Health and safety program a year after dam. Of injectable agents are the same for all common Laboratory animal care and use program on a basis! Unbiased expert assessment, and person who is responsible for monitoring institutional compliance with PHS Policy participating receive... 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